구.농수식품
- 조회1,296
Abstract
Changhoon Park1, Kyuhyung Choi1, Jiwoon Jeong, Chanhee Chae
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea
Corresponding author : Chanhee Chae
Abstract
The objective of the present study was to determine the cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine against heterologous type 1 PRRSV challenge in growing pigs. The mean rectal temperature and respiratory score was significantly (P < 0.05) lower in vaccinated challenged pigs than in unvaccinated challenged pigs. Vaccination of pigs with type 2 PRRSV reduced the levels of type 1 PRRSV viremia after challenge with type 1 PRRSV. Vaccinated challenged pigs had significantly (P < 0.05) higher frequency of interferon-γ secreting cells and lower levels of interleukin-10 compared to unvaccinated challenged pigs. Vaccination of pigs with the type 2 PRRSV effectively reduced the macroscopic and microscopic lung lesion and the type 1 PRRSV antigens within lung lesions in vaccinated challenged pigs. This study demonstrates partial cross-protection of a new type 2 PRRSV modified live vaccine against heterologous type 1 PRRSV challenge in growing pigs
Keywords : Cross-protection; Genotype; Porcine reproductive and respiratory syndrome virus; Vaccine
1Both authors contributed equally to this work
논문정보
- Research article
- 2015년 02월 (BRIC 등록일 2015-03-05)
- 국내 연구진
- 구・농수식품
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