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Abstract
Oju Jeon1, David W. Wolfson1 and Eben Alsberg1,2,*
1 Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
2 Department of Orthopaedic Surgery, Case Western Reserve University, Cleveland, OH, USA
*Corresponding author
Abstract
The spontaneous formation of coacervate microdroplet-laden photo-crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug-laden microdroplets and encapsulation of stem cells in photopolymerized coacervate hydrogels under physiological conditions. This can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulate stem cells for therapeutic applications.
Keywords: alginate; coacervate; gelatin; microdroplet; microencapsulation
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