한빛사논문
- 조회2,368
Abstract
Choong-Wan Woo1,2, Mathieu Roy1,2, Jason T. Buhle3, Tor D. Wager1,2*
1 Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, United States of America, 2 Institute of Cognitive Science, University of Colorado, Boulder, Colorado, United States of America, 3 Department of Psychology, Columbia University, New York, New York, United States of America
*Corresponding Author : Tor D. Wager
Abstract
Cognitive self-regulation can strongly modulate pain and emotion. However, it is unclear whether self-regulation primarily influences primary nociceptive and affective processes or evaluative ones. In this study, participants engaged in selfregulation to increase or decrease pain while experiencing multiple levels of painful heat during functional magnetic resonance imaging (fMRI) imaging. Both heat intensity and self-regulation strongly influenced reported pain, but they did so via two distinct brain pathways. The effects of stimulus intensity were mediated by the neurologic pain signature (NPS), an a priori distributed brain network shown to predict physical pain with over 90% sensitivity and specificity across four studies. Self-regulation did not influence NPS responses; instead, its effects were mediated through functional connections between the nucleus accumbens and ventromedial prefrontal cortex. This pathway was unresponsive to noxious input, and has been broadly implicated in valuation, emotional appraisal, and functional outcomes in pain and other types of affective processes. These findings provide evidence that pain reports are associated with two dissociable functional systems: nociceptive/affective aspects mediated by the NPS, and evaluative/functional aspects mediated by a fronto-striatal system.
논문정보
- Research article
- 2015년 01월 (BRIC 등록일 2015-01-12)
- 국외 연구진
- 바이오·의료융합 > 뇌인지과학
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