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J. Control. Release, Volume 141, Issue 1, 4 January 2010, Pages 2–12 | doi:10.1016/j.jconrel.2009.09.010 Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives

Abstract

Eun Ju Oh^a, Kitae Park^b, Ki Su Kim^a, Jiseok Kim^a, Jeong-A Yang^a, Ji-Hyun Kong^a, Min Young Lee^a, Allan S. Hoffman^c, Sei Kwang Hahn^{a, b,*}

^a Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang 790-784, Republic of Korea
^b School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang 790-784, Republic of Korea
^c Department of Bioengineering, University of Washington, Box 351720, Seattle, WA 98195, USA

^*Corresponding author

Abstract
Hyaluronic acid (HA) is a biodegradable, biocompatible, non-toxic, non-immunogenic and non-inflammatory linear polysaccharide, which has been used for various medical applications such as arthritis treatment, ocular surgery, tissue augmentation, and so on. In this review, the effect of chemical modification of HA on its distribution throughout the body was reported for target specific and long-acting delivery applications of protein, peptide, and nucleotide therapeutics. According to the real-time bio-imaging of HA derivatives using quantum dots (QDot), HA-QDot conjugates with 35 mol% HA modification maintaining enough binding sites for HA receptors were mainly accumulated in the liver, while those with 68 mol% HA modification losing much of HA characteristics were evenly distributed to the tissues in the body. The results are well matched with the fact that HA receptors are abundantly present in the liver with a high specificity to HA molecules. Accordingly, slightly modified HA derivatives were used for target specific intracellular delivery of nucleotide therapeutics and highly modified HA derivatives were used for long-acting conjugation of peptide and protein therapeutics. HA has been also used as a novel depot system in the forms of physically and chemically crosslinked hydrogels for various protein drug delivery. This review will give you a peer overview on novel HA derivatives and the latest advances in HA-based drug delivery systems of various biopharmaceuticals for further clinical development.

논문정보

형식Review Paper
게재일2010년 01월 (BRIC 등록일 2014-12-15)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질
피인용횟수120회 이상 인용된 논문

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