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Small, Volume 4, Issue 6, pages 746–750, June 2008 | DOI: 10.1002/smll.200700954
Analysis of the Toxic Mode of Action of Silver Nanoparticles Using Stress-Specific Bioluminescent Bacteri
Abstract
Ee Taek Hwang1,‡, Jin Hyung Lee2,‡, Yun Ju Chae1, Yeon Seok Kim1, Byoung Chan Kim3, Byoung-In Sang4 and Man Bock Gu1,*
1 College of Life Sciences and Biotechnology, Korea University Seoul (Republic of Korea)
2 Department of Environmental Science and Engineering Gwangju Institute of Science and Technology Gwangju (Republic of Korea)
3 Diagnostics Group, Institut Pasteur Korea Seoul (Republic of Korea)
4 Hazardous Substances Research Center Korea Institute of Science and Technology Seoul (Republic of Korea)
‡These authors contributed equally to this work.
* Corresponding Author.
Abstract
Every cell has a silver lining! The toxicity of Ag nanoparticles is investigated using a panel of recombinant bioluminescent bacteria. The presence of the nanoparticles leads to the production of a superoxide radical (see figure). Furthermore, the Ag nanoparticles damage the cellular membranes, causing a disruption in the ion efflux system. Thus, the cells cannot effectively extrude the Ag ions and, hence, Ag nanoparticles cause more damage than do Ag ions.
Keywords: bioluminescence; cell damage; reactive oxygen species; silver nanoparticles; toxicology
논문정보
- Research article
- 2008년 06월 (BRIC 등록일 2014-12-10)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
- 120회 이상 인용된 논문
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