한빛사논문
- 조회1,768
Abstract
Naeun Lee1, Sungyong You2,*, Min Sun Shin1,*, Won-Woo Lee1,3, Ki Soo Kang1,4, Sang Hyun Kim1,5, Wan-Uk Kim6, Robert J. Homer1,7, Min-Jong Kang1, Ruth R. Montgomery1, Charles S. Dela Cruz1, Albert C. Shaw1, Patty J. Lee1, Geoffrey L. Chupp1, Daehee Hwang2 6 and Insoo Kang1,7 **
1,7 Departments of Internal Medicine and Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
2 Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea
3 Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea
4 Department of Pediatrics, Jeju National University School of Medicine, Jeju, 690-756, Republic of Korea
5 Department of Microbiology, College of Medicine, Kangwon National University, Chuncheon, 200-701, Republic of Korea
6 Department of Internal Medicine, School of Medicine, Catholic University of Korea, Seoul, 137-701, Republic of Korea
**Corresponding Author : Insoo Kang
*Equally contributed to this work
Abstract
Rationale: Cytokine receptors can be markers defining different T cell subsets and considered as therapeutic targets. The association of IL-6 and IL-6 receptor alpha (IL-6Rα) with asthma was reported, suggesting their involvement in asthma. Objectives: To determine whether and how IL-6Rα defines a distinct effector memory (EM) CD8+ T cell population in health and disease. Methods: EM CD8+ T cells expressing IL-6Rα (IL-6Rαhigh) were identified in human peripheral blood and analyzed for function, gene and transcription factor expression. The relationship of these cells with asthma was determined using blood and sputum. Measurements and Main results: A unique population of IL-6Rαhigh EM CD8+ T cells was found in peripheral blood. These cells that potently proliferated, survived, and produced high levels of the Th2-type cytokines IL-5 and IL-13 had increased levels of GATA3 and decreased levels of T-bet and Blimp-1 in comparison to other EM CD8+ T cells. In fact, GATA3 was required for IL-6Rα expression. Asthmatic patients had an increased frequency of IL-6Rαhigh EM CD8+ T cells in peripheral blood compared to healthy controls. Also, IL-6Rαhigh EM CD8+ T cells exclusively produced IL-5 and IL-13 in response to asthma-associated respiratory syncytial virus and bacterial superantigens. Conclusions: Human IL-6Rαhigh EM CD8+ T cells is a unique cell subset that may serve as a reservoir for effector CD8+ T cells, particularly the ones producing Th2-type cytokines, and expand in asthma.
KEYWORDS: Human, CD8, IL-6 receptor, Th2 cytokines, asthma
논문정보
- Research article
- 2014년 11월 (BRIC 등록일 2014-11-18)
- 국내+국외 연구진
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