한빛사논문
- 조회1,270
Abstract
Sangbin Han1, Sang Yun Ha2, Cheol-Keun Park2, Jae-Won Joh3, Choon Hyuck D. Kwon3, Ghee Young Kwon2, Gaabsoo Kim1, Mi Sook Gwak1, Woo Kyoung Jeong4, Justin S. Ko1
1 Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2 Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
3 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
4 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Abstract
Background & Aims
The insignificance of pure microsteatosis (MiS) was reported in living donor liver transplantation (LDLT). However, since steatosis is mostly found in a mixed form of macrosteatosis (MaS) and MiS, we aimed to determine the importance of MiS mixed with MaS in LDLT.
Methods
Donor matching and recipient matching were independently performed with unfixed matching ratio. In donor matching, 51 donors with □ 30% MiS mixed with MaS (H-MiS) were matched with 160 donors with □10% MiS mixed with MaS (L-MiS) based on MaS degree, remnant liver volume, and others. In recipient matching, 50 recipients who received H-MiS grafts were matched with 176 recipients who received L-MiS grafts based on MaS degree, graft volume, MELD score, and others.
Results
Median MiS degree was 10% (range 0%?10%) versus 35% (range 30%?80%) in L-MiS livers versus H-MiS livers after both matching. L-MiS and H-MiS donors were not significantly different regarding postoperative biochemical liver function (e.g. peak AST 232 vs. 246 IU/l, P =0.931). L-MiS and H-MiS recipients were not significantly different regarding 2-week graft regeneration (51% for both) and 5-year survival (HR 0.87, 95% CI 0.43-1.76, P =0.699). Post-transplant donor/recipient complication rates were not significantly different, either.
Conclusions
There were no evidences of significant impact of MiS mixed with MaS on post-LDLT outcomes. The results suggest less importance of MiS, and further, no interaction between MiS and MaS. Thus, the risk of steatosis may be determined by the relative composition of MaS and MiS other than total quantitative degree.
Keywords : Injury, Ischemia-Reperfusion; Donors, Living; Grafts; Hepatectomy; Regeneration, Liver; Steatosis, Liver; Transplantation, Liver
논문정보
- Research article
- 2014년 10월 (BRIC 등록일 2014-11-04)
- 국내 연구진
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