서정목 (연세대학교)

한빛사논문

조회2,886

연세대학교

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Adv. Mater., Article first published online: 2 SEP 2014 | DOI: 10.1002/adma.201402273 Switchable Water-Adhesive, Superhydrophobic Palladium-Layered Silicon Nanowires Potentiate the Angiogenic Efficacy of Human Stem Cell Spheroids

Abstract

Jungmok Seo¹, Jung Seung Lee², Kihong Lee², Dayeong Kim¹, Kisuk Yang², Sera Shin¹, Chandreswar Mahata¹, Hwae Bong Jung³, Wooyoung Lee³, Seung-Woo Cho^2,* and Taeyoon Lee^1,*

¹ Nanobio Device Laboratory, School of Electrical and Electronic Engineering, Yonsei University, Seodaemun-Gu, Seoul, Republic of Korea
² Stem Cell and Biomaterial Engineering Laboratory, Department of Biotechnology, Yonsei University, Seodaemun-Gu, Seoul, Republic of Korea
³ Nano Device Laboratory, Department of Materials Science and Engineering, Yonsei University, Seodaemun-gu, Seoul, Republic of Korea

^*Corresponding authors: Seung-Woo Cho, Taeyoon Lee

Jungmok Seo and Jung Seung Lee contributed equally to this work

Abstract
A switchable water-adhesive, superhydrophobic nanowire surface is developed for the formation of functional stem cell spheroids. The sizes of hADSC spheroids are readily controllable on the surface. Our surface increases cell-cell and cell-matrix interaction, which improves viability and paracrine secretion of the spheroids. Accordingly, the hADSC spheroids produced on the surface exhibit significantly enhanced angiogenic efficacy.

Keywords: superhydrophobic surfaces; switchable water adhesion; silicon nanowires; human adipose-derived stem cells; spheroid formation

논문정보

형식Research article
게재일2014년 09월 (BRIC 등록일 2014-09-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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