한빛사논문
- 조회1,988
Abstract
Sunggu Yanga,1, Sungchil Yangb,1, Thais Moreiraa, Gloria Hoffmanc, Greg C. Carlsond, Kevin J. Benderb, Bradley E. Algere, and Cha-Min Tanga,e,f,2
Departments of aNeurology and
ePhysiology, University of Maryland School of Medicine, Baltimore, MD 21201;
bCenter for Integrative Neuroscience, Department of Neurology, University of California, San Francisco, CA 94608;
cDepartment of Biology, Morgan State University, Baltimore, MD 21251;
fBaltimore Veterans Affairs Medical Center, Baltimore, MD 21201; and
dCenter for Neurobiology and Behavior, University of Pennsylvania, Philadelpia, PA 19104-3403
Abstract
To understand the cellular basis of learning and memory, the neurophysiology of the hippocampus has been largely examined in thin transverse slice preparations. However, the synaptic architecture along the longitudinal septo-temporal axis perpendicular to the transverse projections in CA1 is largely unknown, despite its potential significance for understanding the information processing carried out by the hippocampus. Here, using a battery of powerful techniques, including 3D digital holography and focal glutamate uncaging, voltage-sensitive dye, two-photon imaging, electrophysiology, and immunohistochemistry, we show that CA1 pyramidal neurons are connected to one another in an associational and well-organized fashion along the longitudinal axis of the hippocampus. Such CA1 longitudinal connections mediate reliable signal transfer among the pyramidal cells and express significant synaptic plasticity. These results illustrate a need to reconceptualize hippocampal CA1 network function to include not only processing in the transverse plane, but also operations made possible by the longitudinal network. Our data will thus provide an essential basis for future computational modeling studies on information processing operations carried out in the full 3D hippocampal network that underlies its complex cognitive functions.
longitudinal axons, CA1 association fibers, sequence memory, DHR
1Sunggu Yang and Sungchil Yang contributed equally to the work.
2To whom correspondence should be addressed.
Author contributions: Sunggu Yang and C.-M.T. designed research; Sunggu Yang, Sungchil Yang, T.M., and G.H. performed research; G.C.C. contributed new reagents/analytic tools; Sunggu Yang, Sungchil Yang, G.C.C., and K.J.B. analyzed data; and Sunggu Yang, B.E.A., and C.-M.T. wrote the paper.
논문정보
- Research article
- 2014년 08월 (BRIC 등록일 2014-08-25)
- 국외 연구진
- 바이오·의료융합 > 뇌인지과학
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