한빛사논문
- 조회3,185
Juhyun Oh1,2, Yang David Lee1-3 & Amy J Wagers1,2,4,*
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA. 2Joslin Diabetes Center, Boston, Massachusetts, USA. 3Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA. 4Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.
*Correspondence to: Amy J Wagers
Abstract
Aging tissues experience a progressive decline in homeostatic and regenerative capacities, which has been attributed to degenerative changes in tissue-specific stem cells, stem cell niches and systemic cues that regulate stem cell activity. Understanding the molecular pathways involved in this age-dependent deterioration of stem cell function will be critical for developing new therapies for diseases of aging that target the specific causes of age-related functional decline. Here we explore key molecular pathways that are commonly perturbed as tissues and stem cells age and degenerate. We further consider experimental evidence both suppoxrting and refuting the notion that modulation of these pathways per se can reverse aging phenotypes. Finally, we ask whether stem cell aging establishes an epigenetic 'memory' that is indelibly written or one that can be reset.
논문정보
- Review Paper
- 2014년 08월 (BRIC 등록일 2014-08-21)
- 국외 연구진
- 생명과학 > 생리학
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
