한빛사논문
- 조회3,599
Abstract
Su-Ji Jeon , Seon-Yeong Kwak , DaBin Yim , Jong-Min Ju , and Jong-Ho Kim *
Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea
*Corresponding authors
Abstract
Designing artificial nanomaterials capable of selectively detecting targets without the use of expensive and fragile antibodies is of great interest in the applications of nanomedicine. Here, we show that the photoluminescence (PL) of graphene oxide (GO) was chemically modulated for the selective detection of a neurotransmitter without the use of antibodies. GO was functionalized with nitrotriacetic acid (NTA) on which four different metal ions were chelated (M-NTA-GO), which led to its different PL responses to neurotransmitters. In particular, the Cu-NTA-GO hybrid was able to selectively detect norepinephrine at nanomolar concentrations in a simple manner via its “turn-on” PL. Moreover, it was successfully applied to the selective detection of norepinephrine secreted from living PC-12 cells.
논문정보
- Research article
- 2014년 07월 (BRIC 등록일 2014-08-18)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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