한빛사논문
- 조회2,413
Abstract
Jae-Hyun Lee†, Ji-wook Kim†, Michael Levy‡, Albert Kao‡, Seung-hyun Noh†, Dolores Bozovic‡§*, and Jinwoo Cheon†*
† Department of Chemistry, Yonsei University, Seoul 120-749, Korea
‡ Department of Physics and Astronomy, University of California, Los Angeles, California 90095, United States
§ California NanoSystem Institute, University of California, Los Angeles, California 90095, United States
*Correspondence
Abstract
We introduce cubic magnetic nanoparticles as an effective tool for precise and ultrafast control of mechanosensitive cells. The temporal resolution of our system is 1000 times faster than previously used magnetic switches and is comparable to the current state-of-the-art optogenetic tools. The use of a magnetism-gated switch reported here can address the key challenges of studying mechanotransduction in biological systems. The cube-shaped magnetic nanoparticles are designed to bind to components of cellular membranes and can be controlled with an electromagnet to exert pico-Newtons of mechanical force on the cells. The cubic nanoparticles can thus be used for noncontact mechanical control of the position of the stereocilia of an inner ear hair cell, yielding displacements of tens of nanometers, with sub-millisecond temporal resolution. We also prove that such mechanical stimulus leads to the influx of ions into the hair cell. Our study demonstrates that a magnetic switch can yield ultrafast temporal resolution, and has capabilities for remote manipulation and biological specificity, and that such magnetic system can be used for the study of mechanotransduction processes of a wide range of sensory systems.
Keywords: magnetic nanoparticle; magnetic stimulation; hair cell; mechanosensitive ion channel
논문정보
- Research article
- 2014년 07월 (BRIC 등록일 2014-07-15)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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