한빛사논문
- 조회4,095
Abstract
Su Eun Chung1,2,3,*, Jiyun Kim1,2,3,*, Dong Yoon Oh1,3,4, Younghoon Song1,2,3, Sung Hoon Lee2, Seungki Min2 & Sunghoon Kwon1,2,3
1 Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul National University, Gwanakro, Gwanak-gu, Seoul 151-744, South Korea.
2 Department of Electrical and Computer Engineering, Seoul National University, Gwanakro, Gwanak-gu, Seoul 151-744, South Korea.
3 Inter-university Semiconductor Research Center, Seoul National University, Gwanakro, Gwanak-gu, Seoul 151-744, South Korea.
4 Interdisciplinary program of Bioengineering, Seoul National University, Gwanakro 1, Gwanak-gu, Seoul 151-744, South Korea.
* These authors contributed equally to this work.
Correspondence to : Sunghoon Kwon
Abstract
One quantitative liquid handling method in conventional assay processes is pipetting, which delivers a precise volume of one sample at a time. As this process becomes laborious and time-consuming as the number of samples increases, researchers in individual laboratories need a way to conduct large-scale assays in a reasonable amount of time and at an affordable cost. Here we report a novel handling technique of chemical substances termed ‘partipetting’, which allows the one-step pipetting of various chemical-laden hydrogels. We pipette and assemble various types of encoded chemical-laden microparticles in microwell arrays in parallel. The combination of this heterogeneous particle chip and a cell chip induces the release of the chemicals from the hydrogels and, eventually, the chemicals treat the targets. Based on bioassay applications using partipetting, we show its capability in large-scale bioassays, without the need for high-throughput bioassay resources, owing to a reduction in the assay costs and time.
논문정보
TOP52014년 선정
- Research article
- 2014년 03월 (BRIC 등록일 2014-03-20)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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