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한빛사논문, 상위피인용논문

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The Ohio State University, 현 Vanderbilt University

Proc. Natl. Acad. Sci. USA, published ahead of print March 4, 2014 | doi:10.1073/pnas.1400350111 Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5

Abstract

Taewan Kim^a,1, Ri Cui^a,b, Young-Jun Jeon^a, Ji-Hoon Lee^c, Ju Hee Lee^d, Hosung Sim^e, Jong Kook Park^f, Paolo Fadda^a, Esmerina Tili^a,g, Hiroshi Nakanishi^a, Man-Il Huh^h, Sung-Hak Kim^i,j, Ju Hwan Cho^k, Bong Hwan Sung^l, Yong Peng^a, Tae Jin Lee^a, Zhenghua Luo^a, Hui-Lung Sun^a, Huijun Wei^a, Hansjuerg Alder^a, Jeong Su Oh^m, Kang Sup Shim^a, Sang-Bong Koⁿ, and Carlo M. Croce^a,2

^aDepartment of Molecular Virology, Immunology and Medical Genetics and
^gDepartment of Anesthesiology, Wexner Medical Center, and
ⁱDepartment of Neurological Surgery, The Ohio State University, Columbus, OH 43210;
^bDepartment of Pathology, Affiliated Hospital of YanBian University, YanJi 133002, China;
^cDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75235;
^dDepartment of Applied Mathematics and Statistics, University of California, Santa Cruz, CA 95064;
^eDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109;
^fDepartment of Dermatology, Northwestern University, Chicago, IL 60208;
^hDepartment of Ophthalmology, School of Medicine, Kyungpook National University, Daegu 700-842, Korea;
^jSchool of Life Sciences and Biotechnology, Korea University, Seoul 136-702, Korea;
^kDepartment of Radiation Oncology, The Ohio State University Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210;
^lDepartment of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232;
^mDepartment of Genetic Engineering, Sungkyunkwan University, Suwon 110-745, Korea; and
ⁿDepartment of Orthopedic Surgery, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu 705-718, Korea

Abstract
The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with the rs6983267 allele associated with increased cancer susceptibility. We also found the MYC enhancer region physically interacts with the active regulatory region of the CARLo-5 promoter, suggesting long-range interaction of MYC enhancer with the CARLo-5 promoter regulates CARLo-5 expression. Finally, we demonstrate that CARLo-5 has a function in cell-cycle regulation and tumor development. Overall, our data provide a key of the mystery of the 8q24 gene desert.

¹Present address: Epithelial Biology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232.
²To whom correspondence should be addressed.

논문정보

형식Research article
게재일2014년 03월 (BRIC 등록일 2014-03-07)
연구진국내+국외 연구진
분야
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2017-01-24)

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