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상위피인용논문

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지준호Jun Ho Ji

삼성전자

Inhal. Toxicol., January 2007, Vol. 19, No. 10 , Pages 857-871 | doi: 10.1080/08958370701432108 Twenty-Eight-Day Inhalation Toxicity Study of Silver Nanoparticles in Sprague-Dawley Rats

Abstract

Jun Ho Ji^a, Jae Hee Jung^b, Sang Soo Kim^b, Jin-Uk Yoon^c, Jung Duck Park^d, Byung Sun Choi^d, Yong Hyun Chung^e, Il Hoon Kwon^f, Jayoung Jeong^g, Beom Seok Han^g, Jae Hyeg Shin^h, Jae Hyuck Sungⁱ, Kyung Seuk Songⁱ, Il Je Yu^i*

^a Samsung Electronics Co. Ltd., Suwon, South Korea
^b Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea ^c HCT Co., Icheon, South Korea
^d College of Medicine, Chung-Ang University, Seoul, South Korea
^e Occupational Safety and Health Research Institute, Korea Occupational Safety Health Agency, Daejeon, South Korea
^fNational Institute of Scientific Investigation, Daejeon, South Korea
^g National Institute of Toxicological Research, Seoul, Daejeon, South Korea
^h Korean Agency for Technology and Standards, Seoul, South Korea
ⁱ Korea Environment and Merchandise Testing Institute, Incheon, South Korea
^*Corresponding author

The antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, and home products. Thus, the exposed population continues to increase as the applications expand. Although previous studies on silver dust, fumes, and silver compounds have revealed some insights, little is yet known about the toxicity of nano-sized silver particles, where the size and surface area are recognized as important determinants for toxicity. Thus, the inhalation toxicity of silver nanoparticles is of particular concern to ensure the health of workers and consumers. However, the dispersion of inhalable ambient nano-sized particles has been an obstacle in evaluating the effect of the inhalation of nano-sized particles on the respiratory system. Accordingly, the present study used a device that generates silver nanoparticles by evaporation/condensation using a small ceramic heater. As such, the generator was able to distribute the desired concentrations of silver nanoparticles to chambers containing experimental animals. The concentrations and distribution of the nanoparticles with respect to size were also measured directly using a differential mobility analyzer and ultrafine condensation particle counter.

논문정보

형식Research article
게재일2007년 01월 (BRIC 등록일 2014-02-28)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질
피인용횟수120회 이상 인용된 논문

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