한빛사논문
- 조회2,291
Abstract
Shaul Druckmann1, 5, Linqing Feng2, 5, Bokyoung Lee2, 3, Chaehyun Yook2, 4, Ting Zhao1, Jeffrey C. Magee1, Jinhyun Kim2
1 Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA
2 Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea
3 Neuroscience program, University of Science and Technology, 176 Gajeongdong, Daejeon, 305-350, Korea
4 Department of Biological Science, KAIST, 373-1 Guseongdong, Daejeon, 305-701, Korea
5 These authors contributed equally to this work
Corresponding author : Jeffrey C. Magee, Jinhyun Kim
Summary
The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
논문정보
- Research article
- 2014년 01월 (BRIC 등록일 2014-01-14)
- 국내(교신)+국외 연구진
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