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POSTECH, Harvard Medical School and Massachusetts General Hospital

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ACS Nano, 2014, 8 (1), pp 260–268 | DOI: 10.1021/nn405383a Nanographene Oxide–Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer

Abstract

Ho Sang Jung^†, Won Ho Kong^†, Dong Kyung Sung ^‡, Min-Young Lee^†, Song Eun Beack^†, Do Hee Keum^†, Ki Su Kim ^§, Seok Hyun Yun^§, and Sei Kwang Hahn^†§*

^† Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk 790-784, Korea
^‡ Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul 135-710, Korea
^§Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, United States

^*Correspondence to : Sei Kwang Hahn

Abstract
Melanoma skin cancer is one of the most dangerous skin cancers and the main cause of skin-cancer-related mortality. Hyaluronic acid (HA) has been used as an effective transdermal delivery carrier of chemical drugs and biopharmaceuticals. In this work, a nanographene oxide-HA conjugate (NGO-HA) was synthesized for photothermal ablation therapy of melanoma skin cancer using a near-infrared (NIR) laser. Confocal microscopy and ex vivo bioimaging clearly visualized the remarkable transdermal delivery of NGO-HA to tumor tissues in the skin of mice, which might be ascribed to highly expressed HA receptors and relatively leaky structures around tumor tissues, enabling the enhanced permeation and retention of nanoparticles. The NIR irradiation resulted in complete ablation of tumor tissues with no recurrence of tumorigenesis. The antitumor effect was confirmed by ELISA for caspase-3 activity and histological and immunohistochemical analyses with TUNEL assay for tumor apoptosis. Taken together, we could confirm the feasibility of transdermal NGO-HA for photothermal ablation therapy of melanoma skin cancers.

Keywords: nanographene oxide; hyaluronic acid; photothermal therapy; skin cancer

논문정보

형식Research article
게재일2014년 01월 (BRIC 등록일 2014-01-08)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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