한빛사논문, 상위피인용논문
Abstract
Hyung-Soon Yim1,24, Yun Sung Cho2,24, Xuanmin Guang3,24, Sung Gyun Kang1,4, Jae-Yeon Jeong1,4, Sun-Shin Cha1,4,5, Hyun-Myung Oh1, Jae-Hak Lee1, Eun Chan Yang1, Kae Kyoung Kwon1,4, Yun Jae Kim1, Tae Wan Kim1, Wonduck Kim1, Jeong Ho Jeon1, Sang-Jin Kim1,4, Dong Han Choi1, Sungwoong Jho2, Hak-Min Kim2, Junsu Ko6, Hyunmin Kim6, Young-Ah Shin2, Hyun-Ju Jung6, Yuan Zheng3, Zhuo Wang3, Yan Chen3, Ming Chen3, Awei Jiang3, Erli Li3, Shu Zhang3, Haolong Hou7, Tae Hyung Kim6, Lili Yu3, Sha Liu3, Kung Ahn6, Jesse Cooper6, Sin-Gi Park6, Chang Pyo Hong6, Wook Jin8, Heui-Soo Kim9, Chankyu Park10, Kyooyeol Lee10, Sung Chun11, Phillip A Morin12, Stephen J O’Brien13, Hang Lee14, Jumpei Kimura15, Dae Yeon Moon16, Andrea Manica17, Jeremy Edwards18, Byung Chul Kim2, Sangsoo Kim19, Jun Wang3,20,21, Jong Bhak2,6,22,23, Hyun Sook Lee1,4 & Jung-Hyun Lee1,4
1Korea Institute of Ocean Science and Technology, Ansan, Republic of Korea. 2Personal Genomics Institute, Genome Research Foundation, Suwon, Republic of Korea. 3Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China. 4Department of Marine Biotechnology, University of Science and Technology, Daejeon, Republic of Korea. 5Ocean Science and Technology School, Korea Maritime University, Busan, Republic of Korea. 6Theragen BiO Institute, TheragenEtex, Suwon, Republic of Korea. 7Shaanxi Yulin Energy Group Co. Ltd., Yulin, Shaanxi, China. 8Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Republic of Korea. 9Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea. 10Laboratory of Genome Biology, Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea. 11Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA. 12Marine Mammal and Turtle Division, Southwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, La Jolla, California, USA. 13Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russia. 14College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. 15Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. 16Marine Biodiversity Institute of Korea (MABIK), Ministry of Ocean and Fisheries, Sejong, Republic of Korea. 17Evolutionary Ecology Group, Department of Zoology, University of Cambridge, Cambridge, UK. 18Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. 19School of Systems Biomedical Science, Soongsil University, Seoul, Republic of Korea. 20Department of Biology, University of Copenhagen, Copenhagen, Denmark. 21King Abdulaziz University, Jeddah, Saudi Arabia. 22Program in Nano Science and Technology, Department of Transdisciplinary Studies, Seoul National University, Suwon, Republic of Korea. 23Advanced Institutes of Convergence Technology Nano Science and Technology, Suwon, Republic of Korea. 24These authors contributed equally to this work.
Correspondence to: Jung-Hyun Lee or Hyun Sook Lee or Jong Bhak
The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels.
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