황규상 (KAIST) | 한빛사논문 > 한빛사

한빛사논문

조회2,499

황규상Kyu-Sang Hwang

KAIST

Biotechnol. Adv., Available online 2 November 2013 | http://dx.doi.org/10.1016/j.biotechadv.2013.10.008 Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

Abstract

Kyu-Sang Hwang^{b, 1}, Hyun Uk Kim^{a, b, 1}, Pep Charusanti^a, Bernhard Ø. Palsson^a, Sang Yup Lee^{a, b,*}

^a Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark
^b Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), and Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea

¹ These two authors contributed equally to this work.

^*Corresponding author.

Abstract
Streptomyces species continue to attract attention as a source of novel medicinal compounds. Despite a long history of studies on these microorganisms, they still have many biochemical mysteries to be elucidated. Investigations of novel secondary metabolites and their biosynthetic gene clusters have been more systematized with high-throughput techniques through inspections of correlations among components of the primary and secondary metabolisms at the genome scale. Moreover, up-to-date information on the genome of Streptomyces species with emphasis on their secondary metabolism has been collected in the form of databases and knowledgebases, providing predictive information and enabling one to explore experimentally unrecognized biological spaces of secondary metabolism. Herein, we review recent trends in the systems biology and biotechnology of Streptomyces species.

Abbreviations
ACP, acyl carrier protein; AT, acyltransferase; COBRA, constraint-based reconstruction and analysis; DoBISCUIT, Database Of BIoSynthesis clusters CUrated and InTegrated; MRSA, methicillin-resistant Staphylococcus aureus; NRPS, nonribosomal peptide synthetase; PCP, peptidyl carrier protein; PKS, polyketide synthase; PrISM, Proteomic Investigation of Secondary Metabolism; SBSPKS, Structure Based Sequence Analysis of Polyketide Synthases

Keywords
Streptomyces species; Secondary metabolites; Systems biology; Systems biotechnology; Systems metabolic engineering; Omics techniques; Databases; Knowledgebases; Constraint-based flux analysis

논문정보

형식Review Paper
게재일2013년 11월 (BRIC 등록일 2013-11-27)
연구진국내(교신)+국외 연구진
분야 생명과학 > 응용생물화학

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