한빛사논문, 상위피인용논문
- 조회1,925
Jordan G McCall1-4,14, Tae-il Kim5,6,14, Gunchul Shin7,14, Xian Huang7, Yei Hwan Jung7,13, Ream Al-Hasani1-3, Fiorenzo G Omenetto8,9, Michael R Bruchas1-4,14 & John A Rogers7,10-12,14
1Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, Missouri, USA. 2Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri, USA. 3Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri, USA. 4Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri, USA. 5School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon, Korea. 6IBS Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Daejeon, Republic of Korea. 7Department of Materials Science and Engineering, Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. 8Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA. 9Department of Physics, Tufts University, Medford, Massachusetts, USA. 10Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. 11zzDepartment of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. 12Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. 13Present address: Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Wisconsin, USA. 14These authors contributed equally to
this work.
Correspondence to: Michael R Bruchas or John A Rogers
Abstract
The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. We describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers and their implementation in vivo for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin in vivo experimentation, can be completed in ∼3-8 weeks. Implementation of these devices allows for chronic (tested for up to 6 months) wireless optogenetic manipulation of neural circuitry in animals navigating complex natural or home-cage environments, interacting socially, and experiencing other freely moving behaviors.
논문정보
- Research article
- 2013년 11월 (BRIC 등록일 2013-11-15)
- 국내+국외 연구진
- 120회 이상 인용된 논문 (상위피인용논문 등록일 2021-02-26)
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