한빛사논문
- 조회4,712
Abstract
Justin Farlow1-3, Daeha Seo4-6, Kyle E Broaders1, Marcus J Taylor7, Zev J Gartner1-3 & Young-wook Jun4
1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA. 2Tetrad Graduate Program, University of California San Francisco, San Francisco, California, USA. 3Center for Systems and Synthetic Biology, University of California San Francisco, San Francisco, California, USA. 4Department of Otolaryngology, University of California San Francisco, San Francisco, California, USA. 5Department of Chemistry, University of California Berkeley, Berkeley, California, USA. 6Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. 7Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA.
Correspondence to: Zev J Gartner or Young-wook Jun
Precise control over interfacial chemistry between nanoparticles and other materials remains a major challenge that limits broad application of nanotechnology in biology. To address this challenge, we used 'steric exclusion' to completely convert commercial quantum dots (QDs) into monovalent imaging probes by wrapping each QD with a functionalized oligonucleotide. We demonstrated the utility of these QDs as modular and nonperturbing imaging probes by tracking individual Notch receptors on live cells.
논문정보
- Research article
- 2013년 10월 (BRIC 등록일 2013-10-18)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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