한빛사논문, 상위피인용논문
- 조회3,120
June-Yong Lee, Sara E. Hamilton, Adovi D. Akue, Kristin A. Hogquist, and Stephen C. Jameson1
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55414
1To whom correspondence should be addressed.
Abstract
Previous studies revealed the existence of foreign antigen-specific memory phenotype CD8 T cells in unimmunized mice. Considerable evidence suggests this population, termed “virtual memory” (VM) CD8 T cells, arise via physiological homeostatic mechanisms. However, the antigen-specific function of VM cells is poorly characterized, and hence their potential contribution to immune responses against pathogens is unclear. Here we show that naturally occurring, polyclonal VM cells have unique functional properties, distinct from either naive or antigen-primed memory CD8 T cells. In striking contrast to conventional memory cells, VM cells showed poor T cell receptor-induced IFN-γ synthesis and preferentially differentiated into central memory phenotype cells after priming. Importantly, VM cells showed efficient control of Listeria monocytogenes infection, indicating memory-like capacity to eliminate certain pathogens. These data suggest naturally arising VM cells display unique functional traits, allowing them to form a bridge between the innate and adaptive phase of a response to pathogens.
논문정보
- Research article
- 2013년 07월 (BRIC 등록일 2013-08-06)
- 국외 연구진
- 생명과학 > 면역학
- 120회 이상 인용된 논문 (상위피인용논문 등록일 2021-09-01)
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