한빛사논문, 상위피인용논문
- 조회3,563
Ji Won Um, Jaewon Ko*
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea
*Correspondence to : Jaewon Ko
Abstract
The synapse is the most elementary operating unit in neurons, creating neural circuits that underlie all brain functions. Synaptic adhesion molecules initiate neuronal synapse connections, promote their stabilization and refinement, and control long-term synaptic plasticity. Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) have previously been implicated as essential elements in central nervous system (CNS) development. Recent studies have demonstrated that LAR-RPTP family members are also involved in diverse synaptic functions, playing a role in synaptic adhesion pathways together with a host of distinct transmembrane proteins and serving as major synaptic adhesion molecules in governing pre- and postsynaptic development, dysfunctions of which may underlie various disorders. This review highlights the emerging role of LAR-RPTPs as synapse organizers in orchestrating synapse development.
Keywords : LAR; PTPσ; PTPδ; synapse; synaptic adhesion; receptor protein tyrosine phosphatase
논문정보
- Review Paper
- 2013년 08월 (BRIC 등록일 2013-08-05)
- 국내 연구진
- 생명과학 > 신경생물학
- 120회 이상 인용된 논문 (상위피인용논문 등록일 2020-11-04)
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