한빛사논문
- 조회2,736
Abstract
Kwang-Chul Kwona, Dheeraj Vermaa, Nameirakpam D. Singha, Roland Herzogb, Henry Daniella,*
a Department of Molecular Biology and Microbiology, College of Medicine, University of Central Florida, Biomolecular Science Building, Orlando, FL 32816-2364, USA
b Department of Pediatrics, College of Medicine, University of Florida, Cancer and Genetics Research Complex, 2033 Mowry Road, Gainesville, FL 32610, USA
*Corresponding author at: University of Central Florida, College of Medicine, Department of Molecular Biology and Microbiology, 336 Biomolecular Science Building, Orlando, FL 32816-2364, USA
Abstract
Among 12 billion injections administered annually, unsafe delivery leads to > 20 million infections and > 100 million reactions. In an emerging new concept, freeze-dried plant cells (lettuce) expressing vaccine antigens/biopharmaceuticals are protected in the stomach from acids/enzymes but are released to the immune or blood circulatory system when plant cell walls are digested by microbes that colonize the gut. Vaccine antigens bioencapsulated in plant cells upon oral delivery after priming, conferred both mucosal and systemic immunity and protection against bacterial, viral or protozoan pathogens or toxin challenge. Oral delivery of autoantigens was effective against complications of type 1 diabetes and hemophilia, by developing tolerance. Oral delivery of proinsulin or exendin-4 expressed in plant cells regulated blood glucose levels similar to injections. Therefore, this new platform offers a low cost alternative to deliver different therapeutic proteins to combat infectious or inherited diseases by eliminating inactivated pathogens, expensive purification, cold storage/transportation and sterile injections.
Keywords : Autoantigens; bioencapsulation; diabetes; hemophilia; infectious diseases; lyophilization; molecular farming; oral vaccines
논문정보
- Review Paper
- 2012년 10월 (BRIC 등록일 )
- 국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
