한빛사논문, 상위피인용논문
- 조회5,103
Abstract
Mi Hyeon Cho1†, Eun Jung Lee1,2†, Mina Son2†, Jae-Hyun Lee1, Dongwon Yoo1, Ji-wook Kim1, SeungWoo Park3, Jeon-Soo Shin2,4* and Jinwoo Cheon1,2*
1Department of Chemistry, Yonsei University, Seoul 120-749, Korea, 2Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-749, Korea, 3Department of Internal Medicine, Institute of Gastroenterology, College of Medicine, Yonsei University, Seoul 120-752, Korea, 4Department of Microbiology, Severance Biomedical Science Institute, Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 120-752, Korea.
* Correspondence to: Jeon-Soo Shin or Jinwoo Cheon
† These authors contributed equally to this work.
The regulation of cellular activities in a controlled manner is one of the most challenging issues in fields ranging from cell biology to biomedicine1,2. Nanoparticles have the potential of becoming useful tools for controlling cell signalling pathways in a space and time selective fashion3,4. Here, we have developed magnetic nanoparticles that turn on apoptosis cell signalling by using a magnetic field in a remote and noninvasive manner. The magnetic switch consists of zinc-doped iron oxide magnetic nanoparticles5 (Zn0:4Fe2:6O4), conjugated with a targeting antibody for death receptor 4 (DR4) of DLD-1 colon cancer cells. The magnetic switch, in its On mode when a magnetic field is applied to aggregate magnetic nanoparticlebound DR4s, promotes apoptosis signalling pathways. We have also demonstrated that the magnetic switch is operable at the micrometre scale and that it can be applied in an in vivo system where apoptotic morphological changes of zebrafish are successfully induced.
논문정보
- Research article
- 2012년 10월 (BRIC 등록일 )
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
- 60회 이상 인용된 논문 (상위피인용논문 등록일 2015-10-30)
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