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Curr. Biol., Volume 22, Issue 14, R579-R580, 24 July 2012 | 10.1016/j.cub.2012.06.017
[Dispatch]Stem Cell Niches: Famished Paneth Cells, Gluttonous Stem Cells
Abstract
Tae-Hee Kim and Ramesh A. Shivdasani*
Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA, and Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
*Corresponding author : Ramesh A. Shivdasani
Summary
Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
논문정보
- Dispatch
- 2012년 07월 (BRIC 등록일 )
- 국외 연구진
- 생명과학 > 분자생물학
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