한빛사논문, 상위피인용논문
- 조회3,062
Abstract
Sang-Ho Choi1, Sang-Bum Hong2, Gwang-Beom Ko1, Yumi Lee1, Hyun Jung Park1, So-Youn Park1, Song Mi Moon1, Oh-Hyun Cho1, Ki-Ho Park1, Yong Pil Chong1, Sung-Han Kim1, Jin Won Huh2, Heungsup Sung3, Kyung-Hyun Do4, Sang-Oh Lee1, Mi-Na Kim3, Jin-Yong Jeong1,5, Chae-Man Lim2, Yang Soo Kim1, Jun Hee Woo1 and Younsuck Koh2,*
1Department of Infectious diseases,
2Department of Pulmonary and Critical Care Medicine,
3Department of Laboratory Medicine,
4Department of Radiology,
5Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
*Correspondence: Younsuck Koh
Abstract
Rationale: The role of viruses in pneumonia in adults and the impact of viral infection on mortality have not been elucidated. Previous studies have significant limitations in that they relied predominantly on upper-respiratory specimens.
Objectives: To investigate the role of viral infection in adult patients with pneumonia requiring who intensive care unit (ICU) admission.
Methods: A retrospective analysis of a prospective cohort was conducted in a 28-bed medical ICU Patients with severe community-acquired pneumonia (CAP) or healthcare-associated pneumonia (HCAP) were included in the study.
Measurements and Main Results: A total of 198 patients (64 with CAP, 134 with HCAP) were included for analysis. Of these, 115 patients (58.1%) underwent bronchoscopic bronchoalveolar lavage (BAL), 104 of which were tested for respiratory viruses by BAL fluid reverse-transcription PCR (RT-PCR). Nasopharyngeal specimen RT-PCR was performed in 159 patients (84.1%). Seventy-one patients (35.9%) had a bacterial infection, and 72 patients (36.4%) had a viral infection. Rhinovirus was the most common identified virus (23.6%), followed by parainfluenza virus (20.8%), human metapneumovirus (18.1%), influenza virus (16.7%), and respiratory syncytial virus (13.9%). Respiratory syncytial virus was significantly more common in the CAP group (CAP, 10.9%; HCAP, 2.2%; P = 0.01). The mortalities of patients with bacterial infections, viral infections, and bacterial-viral coinfections were not significantly different (25.5%, 26.5%, and 33.3%, respectively, P = 0.82).
Conclusions: Viruses are frequently found in the airway of patients with pneumonia requiring ICU admission and may cause severe forms of pneumonia. Patients with viral infection and bacterial infection had comparable mortality rates.
논문정보
- Research article
- 2012년 06월 (BRIC 등록일 )
- 국내 연구진
- 의약학 > 응용의학
- 120회 이상 인용된 논문 (상위피인용논문 등록일 2020-07-16)
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