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한빛사논문, 상위피인용논문

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University of Cambridge

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Nat. Rev. Neurosci., 13, 308-324 (May 2012) | doi:10.1038/nrn3210 Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair

Abstract

Hosung Jung¹, Byung C. Yoon¹ & Christine E. Holt^1,*

¹Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

^*Correspondence to: Christine E. Holt

mRNAs can be targeted to specific neuronal subcellular domains, which enables rapid changes in the local proteome through local translation. This mRNA-based mechanism links extrinsic signals to spatially restricted cellular responses and can mediate stimulus-driven adaptive responses such as dendritic plasticity. Local mRNA translation also occurs in growing axons where it can mediate directional responses to guidance signals. Recent profiling studies have revealed that both growing and mature axons possess surprisingly complex and dynamic transcriptomes, thereby suggesting that axonal mRNA localization is highly regulated and has a role in a broad range of processes, a view that is increasingly being supported by new experimental evidence. Here, we review current knowledge on the roles and regulatory mechanisms of axonal mRNA translation and discuss emerging links to axon guidance, survival, regeneration and neurological disorders.

논문정보

형식Review Paper
게재일2012년 04월 (BRIC 등록일 )
연구진국외 연구진
분야 의약학 > 분자세포의학
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2014-09-22)

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