한빛사논문
- 조회4,460
Abstract
Dr. Xinglu Huang1, Magdalena Swierczewska1,2, Dr. Ki Young Choi1, Dr. Lei Zhu1, Dr. Ashwinkumar Bhirde1, Dr. Jinwoo Park3, Dr. Kwangmeyung Kim4, Prof. Jin Xie5, Dr. Gang Niu1, Prof. Kang Choon Lee6, Dr. Seulki Lee1,*, Dr. Xiaoyuan Chen1,*
1Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH, USA)
2Department of Biomedical Engineering, Stony Brook University (USA)
3BioActs, DKC Corporation (Korea)
4Center for Theragnosis, Korea Institute of Science and Technology (KIST, Korea)
5Department of Chemistry and Bio-Imaging Research Center, University of Georgia (USA)
6College of Pharmacy, SungKyunKwan University (Korea)
*Correspondence: Dr. Seulki Lee, Dr. Xiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine (LOMIN) National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH, USA)
†This work was supported by the Intramural Research Program of the NIBIB, NIH and partially supported by an NIH Pathway to Independence (K99/R00) Award, the Henry M. Jackson Foundation, and the Intramural Research Program of KIST (Korea). We thank Myung Sun Lee for illustrations.
Turn off the lights! A universal nanoquencher that quenches a broad range of visible to near-infrared dyes by using a series of dark quenchers incorporated into a cell-permeable mesoporous silica nanoparticle has been developed. In combination with dye-labeled substrates, this nanoquencher boosts multiple fluorescence signals upon specific proteolysis, which allows real-time imaging of proteolytic cascades (see scheme).
Keywords:caspases;fluorescence;imaging agents;nanoparticles;proteolysis
논문정보
- Research article
- 2012년 01월 (BRIC 등록일 )
- 국내+국외 연구진
댓글 작성 로그인
팝업 닫기관련 링크
연구자 ID
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
