한빛사논문
- 조회3,687
Abstract
Dr. Gang Liu1,2,‡, Dr. Ki Young Choi1,‡, Dr. Ashwinkumar Bhirde1, Magdalena Swierczewska1, Dr. Juan Yin3, Sang Wook Lee4, Prof. Jae Hyung Park5, Prof. Jong In Hong4, Prof. Jin Xie6, Dr. Gang Niu1, Dr. Dale O. Kiesewetter1, Dr. Seulki Lee1,*, Dr. Xiaoyuan Chen1,*
1Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and, Bioengineering (NIBIB), National Institutes of Health (USA)
2Sichuan Key Laboratory of Medical Imaging, North Sichuan Medical College (China)
3National Cancer Institute (NCI), National Institutes of Health (USA)
4Department of Chemistry, Seoul National University (Korea)
5Department of Polymer Science and Engineering, Sungkyunkwan University (Korea)
6Department of Chemistry and Bio-Imaging Research Center, University of Georgia (USA)
*Correspondence: Dr. Seulki Lee, Dr. Xiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and, Bioengineering (NIBIB), National Institutes of Health (USA)
Delivering the goods: Multifunctional, self-assembled, polymeric nanoparticles for the simultaneous delivery of small-molecule drugs and siRNA have been synthesized. The nanoparticles are composed of biodegradable hyaluronic acid, for tumor targeting and cellular delivery, and a high siRNA binding affinity is provided by a ZnII-dipicolylamine analogue as an artificial phosphate-binding receptor (see scheme).
Keywords:dipicolylamines;drug delivery;hyaluronic acid;nanoparticles;siRNA
논문정보
- Research article
- 2011년 11월 (BRIC 등록일 )
- 국내+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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