한빛사논문
- 조회4,176
Abstract
Chun-Woong Parka, Yun-Seok Rheeb, Frederick G. Vogtc, Don Hayes Jr.d, Jay Zwischenbergere, Patrick P. DeLucaa and Heidi M. Mansoura,*
a University of Kentucky College of Pharmacy, Department of Pharmaceutical Sciences-Drug Development Division, 789 S. Limestone St., Lexington, KY 40536-0596, USA
b Gyeongsang National University (GNU), College of Pharmacy, Jinju, Gyeongnam 660?751, Republic of Korea
c Analytical Sciences, Product Development, GlaxoSmithKline, King of Prussia, PA 19406
d The Ohio State University College of Medicine, Departments of Pediatrics, Internal Medicine, and Surgery, Lung and Heart-Lung Transplant Programs, Nationwide Children's Hospital, Columbus, OH 43205, USA.
e University of Kentucky College of Medicine, Departments of Pulmonology, Internal Medicine, and Surgery, Lexington, KY 40536-0284, USA
Abstract
The technical advances in microscopy imaging techniques have been applied to assess the fate of drugs for researching respiratory drug delivery in ex vivo and in vivo experiments. Recent developments in optical imaging (confocal microscopy, multi-photon microscopy, fluorescence imaging (FLI) and bioluminescence imaging (BLI)), and in non-optical imaging (magnetic resonance imaging (MRI), computing tomography (CT), positron-emission tomography (PET) and single-photon-emission computed tomography (SPECT)) are presented with their derivative medical devices. The novel microscopy techniques have been utilized to address many biological questions in basic research and are becoming powerful clinical tools for non-invasive objective diagnosis, guided treatment, and monitoring therapies. The goal of this paper is to present recent advances in microscopy imaging techniques and to discuss their novel applications in respiratory drug delivery imaging.
논문정보
- Review Paper
- 2011년 09월 (BRIC 등록일 )
- 국외 연구진
- 의약학 > 약학
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