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Columbia University Medical Center

Nat. Rev. Neurosci., 12, 284-296 (May 2011) | doi:10.1038/nrn3012 Linking lipids to Alzheimer's disease: cholesterol and beyond

Abstract

Gilbert Di Paolo¹& Tae-Wan Kim¹

^1.Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA.

Correspondence to: Gilbert Di Paolo¹
Correspondence to: Tae-Wan Kim¹

Published online 30 March 2011

* Fig 2 and Fig 3 have been corrected on both html and pdf versions.

Lipid-mediated signalling regulates a plethora of physiological processes, including crucial aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in a growing number of neurodegenerative disorders, such as Alzheimer's disease (AD). Although much attention has been given to the link between cholesterol and AD pathogenesis, growing evidence suggests that other lipids, such as phosphoinositides and phosphatidic acid, have an important role. Regulators of lipid metabolism (for example, statins) are a highly successful class of marketed drugs, and exploration of lipid dysregulation in AD and identification of novel therapeutic agents acting through relevant lipid pathways offers new and effective options for the treatment of this devastating disorder.

논문정보

형식Review Paper
게재일2011년 05월 (BRIC 등록일 )
연구진국외 연구진
분야 생명과학 > 신경생물학
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2014-05-31)

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