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University of Missouri-Columbia

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Cytokine Growth Factor Rev., Available online 19 January 2011. | doi:10.1016/j.cytogfr.2010.12.001 Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

Abstract

Young-Jin Seo^a, Stephen Alexander^b and Bumsuk Hahm^a,

^a Departments of Surgery & Molecular Microbiology and Immunology, Center for Cellular and Molecular Immunology, Virology Center, University of Missouri-Columbia, One Hospital Dr., Columbia, MO 65212, USA
^b Division of Biological Sciences, University of Missouri-Columbia, Columbia, MO 65212, USA

Abstract
Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared to employ a JAK/STAT type I interferon signaling pathway that induces anti-viral status. Further, sphingosine analogs altered cytokine responses upon influenza virus infection. This article focuses on recent discoveries about the sphingolipid system that influences on host protection from viral virulence and the involvement of cytokine signaling in its underlying mechanisms. Deciphering the steps of this pathway could help us envision how the modulation of sphingolipid metabolism can be applied as a therapeutic approach to overcome infectious diseases.

Keywords: Sphingosine kinase; S1P lyase; Influenza virus; Type I IFN; TNF

논문정보

형식Review Paper
게재일2011년 01월 (BRIC 등록일 )
연구진국외 연구진
분야 생명과학 > 미생물학

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