한빛사논문, 상위피인용논문
- 조회6,554
Abstract
Cheolho Cheong,1,5,* Ines Matos,1,5 Jae-Hoon Choi,1 Durga Bhavani Dandamudi,1 Elina Shrestha,1 M. Paula Longhi,1 Kate L. Jeffrey,2 Robert M. Anthony,3 Courtney Kluger,1 Godwin Nchinda,1 Hyein Koh,1 Anthony Rodriguez,1 Juliana Idoyaga,1 Maggi Pack,1 Klara Velinzon,4 Chae Gyu Park,1,* and Ralph M. Steinman1,*
1Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases
2Laboratory of Lymphocyte Signaling
3Laboratory of Molecular Genetics and Immunology
4Laboratory of Molecular Immunology, Howard Hughes Medical Institute
The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
5These authors contributed equally to this work
*Correspondence: C.C., C.G.P., R.M.S.
Summary
Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of DCs in vivo. We now show that fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells. Mo-DCs are recruited from blood monocytes into lymph nodes by lipopolysaccharide and live or dead gram-negative bacteria. Mobilization requires TLR4 and its CD14 coreceptor and Trif. When tested for antigen-presenting function, Mo-DCs are as active as classical DCs, including cross-presentation of proteins and live gram-negative bacteria on MHC I in vivo. Fully differentiated Mo-DCs acquire DC morphology and localize to T cell areas via L-selectin and CCR7. Thus the blood monocyte reservoir becomes the dominant presenting cell in response to select microbes, yielding DC-SIGN+ cells with critical functions of DCs.
논문정보
- Research article
- 2010년 10월 (BRIC 등록일 )
- 국외 연구진
- 60회 이상 인용된 논문 (상위피인용논문 등록일 2012-03-29)
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