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Abstract
Dr. Woo Kyung Cho1, Kyungtae Kang1, Gyumin Kang3, Min Jee Jang3, Prof. Dr. Yoonkey Nam3, Prof. Dr. Insung S. Choi1,2
1Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon 305-701 (Korea), Fax: (+82)42-350-2810 http://cisgroup.kaist.ac.kr
2Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea)
3Department of Bio and Brain Engineering, KAIST, Daejeon 305-701 (Korea), Fax: (+82)42-350-4310 http://neuros.kaist.ac.kr
Correspondence: Prof. Dr. Yoonkey Nam, Prof. Dr. Insung S. Choi
†This research was supported through the Basic Science Research Programs by the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science and Technology (2010-0001953, 2009-0080081, and 2010-0000419), and by the Brain Research Center of the 21st Century Frontier Research Program. I.S.C. thanks the LG Yonam Foundation.
Keywords:anodized aluminum oxide;cell adhesion;nanostructures;neurite outgrowth;neurochemistry
Pitching in to help: When nanostructured anodized aluminum oxide substrates of four different types were used as nanotopographical environments for in vitro neuronal culture, the average neurite outgrowth was much faster on surfaces with a 400 nm pitch than on surfaces with a 60 nm pitch (see AFM images of two substrates and fluorescence micrographs of hippocampal neurons after culture for 2 days on these substrates).
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