김세윤 (Johns Hopkins University School of Medicine)

한빛사논문

조회5,897

Johns Hopkins University School of Medicine

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Nat. Rev. Mol. Cell Bio., 11, 75-81 (January 2010) | doi:10.1038/nrm2818 Emerging role for the cytoskeleton as an organizer and regulator of translation

Abstract

Seyun Kim¹ & Pierre A. Coulombe²

The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the cytoskeleton participates in the spatial organization and regulation of translation, at both the global and local level, in a manner that is crucial for cellular growth, proliferation and function.

Author affiliations

1.Seyun Kim is at The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

2.Pierre A. Coulombe is at Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

Correspondence to: Pierre A. Coulombe²

논문정보

형식Review Paper
게재일2010년 01월 (BRIC 등록일 )
연구진국외 연구진
분야 생명과학 > 생화학

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