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Harvard Medical School

Adv. Drug Deliv. Rev., doi:10.1016/j.addr.2009.11.016 Nano/microfluidics for diagnosis of infectious diseases in developing countries

Abstract

Won Gu Lee^{a, b, 1}, Yun-Gon Kim^{a, b, c, 1}, Bong Geun Chung^{a, b}, Utkan Demirci^{a, b, c,} and Ali Khademhosseini^{a, b}

^aCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA

^bHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

^cBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA

Received 15 June 2009; accepted 14 September 2009. Available online 30 November 2009.

Abstract
Nano/microfluidic technologies are emerging as powerful enabling tools for diagnosis and monitoring of infectious diseases in both developed and developing countries. Miniaturized nano/microfluidic platforms that precisely manipulate small fluid volumes can be used to enable medical diagnosis in a more rapid and accurate manner. In particular, these nano/microfluidic diagnostic technologies are potentially applicable to global health applications, because they are disposable, inexpensive, portable, and easy-to-use for detection of infectious diseases. In this paper, we review recent developments in nano/microfluidic technologies for clinical point-of-care applications at resource-limited settings in developing countries.

Keywords: Nano/microfluidics; Infectious diseases; HIV/AIDS; Point-of-care; Diagnostics; Global health

Abbreviations: AED, antiepileptic drug; AFM, atomic force microscopy; AIDS, acquired immunodeficiency syndrome; ART, antiretroviral therapy; CCD, charge-coupled device; ELISA, enzyme-linked immunosorbent assay; FLASH, fast lithographic activation of sheet; HIV, human immunodeficiency virus; LED, light-emitting diode; LOC, lab-on-a-chip; NMR, nuclear magnetic resonance; PCR, polymerase chain reaction; PDMS, poly (dimethylsiloxane); PMMA, polymethymetacrylate; POC, point-of-care; POCKET, portable and cost-effective; QD, quantum dot; RDT, rapid diagnostic test; RF, radio frequency; SPR, surface plasmon resonance; TB, tuberculosis; WHO, World Health Organization

^☆This review is part of the Advanced Drug Delivery Reviews theme issue on “Nanotechnology Solutions for Infectious Diseases in Developing Nations”.

Corresponding authors. Tel.: +1 617 768 8395; fax: +1 617 768 8477.
¹ These authors equally contributed to this work.

논문정보

형식Review Paper
게재일2009년 11월 (BRIC 등록일 )
연구진국외 연구진
분야
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2012-11-30)

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