상위피인용논문
- 조회2,015
Abstract
Eun Hwa Choi,1,3 Hoan Jong Lee,1,2 Sun Jung Kim,3 Byung Wook Eun,1 Nam Hee Kim,1 Jin A Lee,1 Jun Ho Lee,1 Eun Kyung Song,1 So Hee Kim1 Ji Yong Park,1 and Ji Yeon Sung1
1Department of Pediatrics, Seoul National University College of Medicine, and 2Virus Research Center, Clinical Research Institute, Seoul National University Hospital, Seoul, and 3Seoul Medical Science Research Institute, Seoul National University Bundang Hospital, Gyeonggi-do, Korea
Background.This study was performed to evaluate the associations of newly recognized viruses, namely, human metapneumovirus (hMPV), human coronavirus (HCoV)-NL63, and human bocavirus (HBoV) with lower respiratory tract infections (LRTIs) in previously healthy children.
Methods.To determine the prevalences of 11 viruses-respiratory syncytial virus (RSV), adenovirus, rhinovirus, parainfluenza viruses (PIVs) 1 and 3, influenza viruses A and B, hMPV, HCoV, HCoV-NL63, and HBoV-among infants or children with LRTIs, in association with their epidemiologic characteristics, we performed multiplex reverse-transcriptase polymerase chain reaction on nasopharyngeal aspirates obtained from 515 children < or =5 years old with LRTIs during the period 2000-2005.
Results.Viruses were identified in 312 (60.6%) of the 515 patients. RSV was detected in 122 (23.7%), HBoV in 58 (11.3%), adenovirus in 35 (6.8%), PIV-3 in 32 (6.2%), rhinovirus in 30 (5.8%), hMPV in 24 (4.7%), influenza A in 24 (4.7%), PIV-1 in 9 (1.7%), influenza B in 9 (1.7%), and HCoV-NL63 in 8 (1.6%). Coinfections with > or =2 viruses were observed in 36 patients (11.5%). Twenty-two patients (37.9%) infected with HBoV had a coinfection. Bronchiolitis was frequently diagnosed in patients who tested positive for RSV, PIV-3, or rhinovirus, whereas influenza A, PIV-1, and HCoV-NL63 were commonly found in patients with croup. The age distributions of patients with viral infections differed; notably, RSV was responsible for 77% of LRTIs that occurred in infants < or =3 months old. The number of hMPV infections peaked between February and April, whereas the number of HCoV-NL63 infections peaked between April and May.
Conclusions.This study describes the features of LRTIs associated with newly identified viruses in children, compared with those associated with known viruses. Additional investigations are required to define the role of HBoV in LRTI.
논문정보
- Research article
- 2006년 09월 (BRIC 등록일 )
- 국내 연구진
- 120회 이상 인용된 논문
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