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한빛사논문, 상위피인용논문

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포항공과대학교 / UCLA

Proc. Natl. Acad. Sci. USA, Published online before print September 22, 2005 Transmembrane glycine zippers: Physiological and pathological roles in membrane proteins

Abstract

( amyloid- ${beta}$ | membrane channel | membrane protein structure | prion | transmembrane helix )

Sanguk Kim * ${dagger}$ , Tae-Joon Jeon ${ddagger}$ , Amit Oberai *, Duan Yang *, Jacob J. Schmidt ${ddagger}$ , and James U. Bowie * ${sect}$

^*Department of Chemistry and Biochemistry and UCLA-DOE Institute for Genomics and Proteomics and Department of Bioengineering, University of California, Los Angeles, CA 90095

Edited by Donald M. Engelman, Yale University, New Haven, CT,and approved August 12, 2005 (received for review February 13,2005)

We have observed a common sequence motif in membrane proteins,which we call a glycine zipper. Glycine zipper motifs are stronglyoverrepresented and conserved in membrane protein sequences,and mutations in glycine zipper motifs are deleterious to functionin many cases. The glycine zipper has a significant structuralimpact, engendering a strong driving force for right-handedpacking against a neighboring helix. Thus, the presence of aglycine zipper motif leads directly to testable structural hypotheses,particularly for a subclass of glycine zipper proteins thatform channels. For example, we suggest that the membrane poresformed by the amyloid- ${beta}$ peptide in vitro are constructed by glycinezipper packing and find that mutations in the glycine zippermotif block channel formation. Our findings highlight an importantstructural motif in a wide variety of normal and pathologicalprocesses.

Author contributions: S.K., T.-J.J., A.O., D.Y., J.J.S., and J.U.B. designed research; S.K., T.-J.J., A.O., and D.Y. performed research; T.-J.J., A.O., and D.Y. contributed new reagents/analytic tools; S.K., T.-J.J., A.O., D.Y., J.J.S., and J.U.B. analyzed data; and S.K., T.-J.J., J.J.S., and J.U.B. wrote the paper.

Present address: Department of Life Science, POSTECH, Pohang University of Science and Technology, Pohang, Kyung-Buk 790-784, Korea.

To whom correspondence should be addressed.

논문정보

형식Research article
게재일2005년 09월 (BRIC 등록일 )
연구진국외 연구진
분야 생명과학 > 유전학
피인용횟수120회 이상 인용된 논문 (상위피인용논문 등록일 2014-04-15)

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