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한빛사논문
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Proc. Natl. Acad. Sci. USA, September 29, 2009 vol. 106 no. 39 16841-16846, doi: 10.1073/pnas.0904551106
Segregating the significant from the mundane on a moment-to-moment basis via direct and indirect amygdala contributions
Abstract
Seung-Lark Lim, Srikanth Padmala and Luiz Pessoa1
Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405
Edited by Leslie G. Ungerleider, National Institute of Mental Health, Bethesda, MD, and approved July 31, 2009 (received for review April 27, 2009)
Abstract
If the amygdala is involved in shaping perceptual experience when affectively significant visual items are encountered, responses in this structure should be correlated with both visual cortex responses and behavioral reports. Here, we investigated how affective significance shapes visual perception during an attentional blink paradigm combined with aversive conditioning. Behaviorally, following aversive learning, affectively significant scenes (CS+) were better detected than neutral (CS−) ones. In terms of mean brain responses, both amygdala and visual cortical responses were stronger during CS+ relative to CS− trials. Increased brain responses in these regions were associated with improved behavioral performance across participants and followed a mediation-like pattern. Importantly, the mediation pattern was observed in a trial-by-trial analysis, revealing that the specific pattern of trial-by-trial variability in brain responses was closely related to single-trial behavioral performance. Furthermore, the influence of the amygdala on visual cortical responses was consistent with a mediation, although partial, via frontal brain regions. Our results thus suggest that affective significance potentially determines the fate of a visual item during competitive interactions by enhancing sensory processing through both direct and indirect paths. In so doing, the amygdala helps separate the significant from the mundane.attentional blink, aversive conditioning, emotion, fMRI
Footnotes
1To whom correspondence should be addressed.
Author contributions: S.-L.L., S.P., and L.P. designed research; S.-L.L. performed research; S.P. contributed new reagents/analytic tools; S.-L.L. and S.P. analyzed data; and S.-L.L. and L.P. wrote the paper.
The authors declare no conflicts of interest.
This article is a PNAS Direct Submission.
논문정보
- Research article
- 2009년 09월 (BRIC 등록일 )
- 국외 연구진
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