한빛사논문
- 조회2,453
Abstract
1Laboratoire de Biologie du Development, University Pierre et
Marie Curie, 75005 Paris (France), Fax: (+33) 1-4427-3451
2Department
of Structural Biology,Stop 311, St. Jude Children's Research Hospital, 262 Danny
Thomas Place, Memphis, TN 38105-3678 (USA), Fax: (+1) 901-595-3168 http://www.stjude.org/zheng
*Correspondence to De-Li Shi, 1Laboratoire de Biologie du Development, University Pierre et Marie Curie, 75005 Paris (France), Fax: (+33) 1-4427-3451
*Correspondence to Jie J. Zheng, 2Department of Structural Biology,Stop 311, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678 (USA), Fax: (+1) 901-595-3168 http://www.stjude.org/zheng
This work was supported by NIH grants CA21765 (Cancer Center Support Grant) and GM081492, by the American Lebanese Syrian Associated Charities (ALSAC; J.J.Z.), and to ARC and LNCC (D.-L.S.). We thank Sharon Naron for editing the manuscript; the Hartwell Center for Bioinformatics and Biotechnology at St. Jude for computational time; S. Malone, M. Zhou, and Dr. C. Ross for computer-related technical support; Dr. W. Zhang for assistance with the NMR experiments; and Y. Shao for providing proteins.
Funded by:
NIH; Grant Number: CA21765, GM081492
American
Lebanese Syrian Associated Charities
ARC
LNCC
Keywords
antitumor agents, hydrogen bonds, signal inhibition, signal
transduction
Abstract
A new application: The nonsteroidal anti-inflammatory drug sulindac interacts directly and specifically with the PDZ domain of the protein Dishevelled (Dvl), which is a key intracellular component of the Wnt signaling pathways. Sulindac binds to the conventional peptide-binding pocket of the domain (see picture), and may exert a cancer chemoprotective effect by blocking it, thereby inhibiting canonical Wnt signaling.
논문정보
- Research article
- 2009년 08월 (BRIC 등록일 )
- 국외 연구진
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