김정수 (Washington University School of Medicine) | 한빛사논문 > 한빛사

한빛사논문, 상위피인용논문

조회5,366

Washington University School of Medicine

Neuron, Volume 63, Issue 3, 287-303, 13 August 2009 The Role of Apolipoprotein E in Alzheimer's Disease

Abstract

Jungsu Kim¹, Jacob M. Basak¹ and David M. Holtzman^1,*

¹ Department of Neurology, Developmental Biology, Hope Center for Neurological Disorders, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA

^* Corresponding author

Summary

The ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evidence suggests that the differential effects of apoE isoforms on A{beta} aggregation and clearance play the major role in AD pathogenesis. Other potential mechanisms, such as the differential modulation of neurotoxicity and tau phosphorylation by apoE isoforms as well as its role in synaptic plasticity and neuroinflammation, have not been ruled out. Inconsistent results among studies have made it difficult to define whether the APOE ε4 allele represents a gain of toxic function, a loss of neuroprotective function, or both. Therapeutic strategies based on apoE propose to reduce the toxic effects of apoE4 or to restore the physiological, protective functions of apoE.

논문정보

형식Review Paper
게재일2009년 08월 (BRIC 등록일 )
연구진국외 연구진
분야 생명과학 > 신경생물학
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2010-11-22)

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