Young-Kwang Kim ^a,d,1, Yun Jae Cha ^a,1, Se Eun Park ^a,d, Hee Kyung Kim ^a,d, Chaesun Kwon ^a,d, Geonmo Kim ^a,d, Yoonah R. Oh ^a,d, Edwin Vázquez-Rosa ^e,f,g, Ujjwal Dahiya ^h, Helen Moinova ⁱ, Yeojung Koh ^e,f,g,j, Farrah Gao ^k, Sunil Jamuna Tripathi ^l, Suwarna Chakraborty ^l, Dong-Gyu Jo ^m, Minseo Woo ⁿ, Hyejin Park ⁿ, Seung-Jae Myung ^o,p,q, Jiwon Cheon ^r, Yunjong Lee ^r, Xin Qi ^s, Bindu D. Paul ^l,t,u, Stephen Fink ^h, Lakshmi Kasturi ^h, James Lutterbaugh ^h, Sanford D. Markowitz ^h,i,v, Andrew A. Pieper ^e,f,g,j,w,x, Yun Pyo Kang ^a, Min-Kyoo Shin <sup>a,b,c,d

a</sup>College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
^bNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
^cInnovative Pharmaceutical Sciences Program, College of Transdisciplinary Innovations, Seoul National University, Seoul, Republic of Korea
^dLaboratory of Neurodegenerative Diseases, College of Pharmacy, Seoul National University, Seoul, Republic of Korea
^eDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
^fGeriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH, USA
^gInstitute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
^hCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
ⁱDepartment of Medicine, Case Western Reserve University, Cleveland, OH, USA
^jDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA
^kDepartment of Genetics and Genome Sciences School of Medicine, Case Western Reserve University, Cleveland, OH, USA
^lDepartment of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
^mSchool of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea
ⁿGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
^oDigestive Diseases Research Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
^pDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
^qEdis Biotech, Songpa-gu, Seoul, Republic of Korea
^rDepartment of Pharmacology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
^sDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
^tDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
^uThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
^vSeidman Cancer Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
^wBrain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
^xDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH, USA

¹Authors contributed equally.
Corresponding authors: Sanford D. Markowitz, Andrew A. Pieper, Yun Pyo Kang, Min-Kyoo Shin