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Gut, May 04 2026, gutjnl-2026-338084 | https://doi.org/10.1136/gutjnl-2026-338084 Maternal influenza infection during pregnancy and subsequent risk of inflammatory bowel diseases in offspring: a nationwide birth cohort study in South Korea

Yujin Choi^1,2,†, Hyunjee Kim^1,3,†, Jaeyu Park^1,3,†, Dongjin Yeo^1,4, Jiseung Kang^5,6, Dong Keon Yon ^1,3,4,7,*

¹Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
²Department of Korean Medicine, Kyung Hee University College of Korean Medicine, Seoul, South Korea.
³Department of Precision Medicine, Kyung Hee University School of Medicine, Seoul, South Korea.
⁴Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
⁵Department of Health and Safety Convergence Science, Korea University Graduate School, Seoul, South Korea.
⁶School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.
⁷Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

^†YC, HK and JP contributed equally

^*Corresponding author: correspondence to Dong Keon Yon

Abstract

We read with interest the commentary by Ashton JJ et al. Paediatric inflammatory bowel disease (IBD) may persist into adulthood, underscoring the importance of identifying factors that may influence disease development early in life. Therefore, we aimed to investigate the risk of IBD in children born to women infected with influenza during pregnancy. This nationwide, large-scale, population-based birth cohort included children born between 1 January 2010 and 31 December 2017, using data from the National Health Insurance Service of Korea (NHIS), with follow-up through 31 December 2023.

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