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고려대학교

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Adv. Drug Deliv. Rev., 61 (2009) 850–862 siRNA delivery systems for cancer treatment

Abstract

Yu-Kyoung Oh ^a, Tae Gwan Park ^b,*

^a School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
^b Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, South Korea

Abstract

With increasing knowledge on the molecular mechanisms of endogenous RNA interference, small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines for treatment of incurable diseases such as cancers. Although several siRNA candidates for the treatment of ocular and respiratory diseases are undergoing clinical trials, there are challenges inherent in the further development of siRNAs for anti-cancer therapeutics, because systemic administration will be required in most cases. In addition to nonspecific off-target and immune stimulation problems, appropriate delivery remains a major hurdle. The technologies developed for delivery of nucleic acid medicines such as plasmid DNA and antisense oligonucleotides have paved the way to rapid progress for in vivo delivery of siRNAs. Here, we review various in vivo delivery strategies including chemical modification, conjugation, lipid-based techniques, polymer-based nanosystems, and physical methods. Moreover, the current progress in siRNA delivery systems for gynecologic, liver, lung, and prostate cancers is discussed.

Keywords: RNA interference, Cancer, siRNA delivery, Lipoplex, Polyplex, Targeted delivery

This review is part of the Advanced Drug Delivery Reviews theme issue on "The Role of Gene– and Drug Delivery in Women's Health – Unmet Clinical Needs and Future Opportunities".

^* Corresponding author. Tel.: +82 42 869 2621; fax: +82 42 869 2610.

논문정보

형식Review Paper
게재일2009년 07월 (BRIC 등록일 )
연구진국내 연구진
분야 의약학 > 약학
피인용횟수60회 이상 인용된 논문 (상위피인용논문 등록일 2011-10-17)

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