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연혜정Hyejeong Yeon

KAIST

Mater. Horizons, Feb 05 2026, | https://doi.org/10.1039/d5mh02129d A self-regulating wearable OLED patch for accelerated wound healing via photobiomodulation-triggered drug delivery

Hyejeong Yeon,^†a Sohyeon Yu,^†bc Minhyeok Lee,^†d Sangwoo Kim,^†bc Yongjin Park,^a Hye-Ryung Choi,^e Won Il Choi,^b Chang-Hun Huh,^e Yongmin Jeon,^*f Chan-Su Park,^*d Daekyung Sung^*b and Kyung Cheol Choi^*a

^aSchool of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
^bCenter for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, Republic of Korea
^cDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea
^dDepartment of Pharmaceutics, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea
^eDepartment of Dermatology, Seoul National University Bundang Hospital (SNUBH), Seongnam, Republic of Korea
^fDepartment of Information Display, Kyung Hee University, Seoul, Republic of Korea

^†These authors contributed equally to this work.
^*Corresponding authors

Abstract

The development of therapies that dynamically respond to the wound microenvironment is essential to overcome the limitations of conventional monotherapies. We present a wearable patch that self-regulates reactive oxygen species (ROS) to accelerate wound healing. This flexible organic light-emitting diode (OLED) patch conforms to the wound, delivering narrow 630 nm peak light at an irradiance of 5 mW cm^-2 for photobiomodulation (PBM). The patch activates healing directly via PBM, and the consequently induced ROS serve as a therapeutic trigger. This ROS trigger stimulates ROS-responsive nanoparticles to release antioxidant drugs, which neutralize excess ROS. We confirmed a dose-dependent additive effect across 2-8 J cm^-2, with 6 J cm^-2 being the most effective. This combination therapy significantly accelerated wound closure and promoted superior tissue regeneration, including robust skin barrier reconstruction and mature vessel stabilization. This OLED patch introduces a next-generation phototherapy, transforming signals into therapeutic triggers for advanced combination treatments.

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