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최종업데이트 2026.01.09.

TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease
- Int. J. Biol. Sci., 2026; 22(3):1103-1125 | https://doi.org/10.7150/ijbs.126251
- 2026-01
- 의약학
- 한빛사논문
Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families
- J. Adv. Res., Available online 3 December 2025 | https://doi.org/10.1016/j.jare.2025.11.066
- 2025-12
- 의약학
- 한빛사논문
Hepatocyte TM4SF5-mediated cytosolic NCOA3 stabilization and macropinocytosis support albumin uptake and bioenergetics for hepatocellular carcinoma progression
- Exp. Mol. Med., Apr 04 2025, | https://doi.org/10.1038/s12276-025-01438-9
- 2025-04
- 의약학
- 한빛사논문
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage
- Signal Transduct. Target. Ther., Jan 20 2025, 10 (1) | https://doi.org/10.1038/s41392-024-02106-6
- 2025-01
- 의약학
- 한빛사논문
Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites
- Cancer Commun., Dec 22 2023, | https://doi.org/10.1002/cac2.12510
- 2023-12
- 의약학
- 한빛사논문
Differential ligand binding/trafficking for distinct CTLA-4 fates: is it an expandable mechanism?
- Cell. Mol. Immunol., 2023 Jan;20(1):1-2 | doi: 10.1038/s41423-022-00945-3
- 2023-01
- 의약학
- 한빛사논문
Liver-originated small extracellular vesicles with TM4SF5 target brown adipose tissue for homeostatic glucose clearance
- J. Extracell. Vesicles, Volume11, Issue9 September 2022 e12262 | https://doi.org/10.1002/jev2.12262
- 2022-09
- 의약학
- 한빛사논문
TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
- Cell Reports, VOLUME 37, ISSUE 7, 110018, NOVEMBER 16, 2021 | https://doi.org/10.1016/j.celrep.2021.110018
- 2021-11
- 의약학
- 한빛사논문
N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application
- Theranostics, Published 2021-7-6, 11(16):8092-8111 | doi:10.7150/thno.58739
- 2021-07
- 의약학
- 한빛사논문
Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
- Cell Metab., Published: April 4, 2019 | DOI:https://doi.org/10.1016/j.cmet.2019.03.005
- 2019-04
- 의약학
- 한빛사논문

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