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In brief, we found that a chemical imbalance that mechanistically explains a cellular imbalance in patients with lupus (compared to healthy controls). Correcting this chemical imbalance appears to be a useful therapeutic approach for this disease.
Nature2024-07-15
Adoptive T cell therapies have produced spectacular results in multiple treatment-related diseases. However, they have failed to make a significant impact on solid tumors, which represent >90% of all adult cancers. Solid tumors have an immunosuppressive microenvironment that limits T cell persistence and potency. To overcome this barrier and address the important clinical unmet need, we turned to extranodal T cell lymphomas, which develop mutations that increase T cell fitness in analogous microenvironments.
Nature2024-02-20