심재혁 (University of Massachusetts Chan Medical School)님 | 한빛사연구자 > 한빛사

Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases

Mol. Ther., Sep 10 2025, S1525-0016(25)00736-1 | https://doi.org/10.1016/j.ymthe.2025.09.008

Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss

Mol. Ther., Jun 26 2024, S1525-0016(24)00426-X | https://doi.org/10.1016/j.ymthe.2024.06.036

Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis

Proc. Natl. Acad. Sci. USA, May 4, 2023 120 (19) e2218019120 | https://doi.org/10.1073/pnas.2218019120

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery

Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects

Mol. Ther., 2022 Oct 3;S1525-0016(22)00607-4 | https://doi.org/10.1016/j.ymthe.2022.09.018

AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

Mol. Ther.-Nucl. Acids, Volume 29, 13 September 2022, Pages 296-311 | https://doi.org/10.1016/j.omtn.2022.07.008

Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes

Cell Death Differ., Published 15 February 2022 | https://doi.org/10.1038/s41418-022-00952-x

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

Nat. Commun., Published: 08 May 2020 11, Article number: 2289 (2020) | https://doi.org/10.1038/s41467-020-16038-6

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

Nat. Commun., Published 04 July 2019, 10, Article number: 2958 | https://doi.org/10.1038/s41467-019-10809-6

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