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최종업데이트 2025.11.04.

Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var
- Nat. Commun., 03 November 2025;16, 9690(2025) | https://doi.org/10.1038/s41467-025-64730-2
- 2025-11
- 의약학
- 한빛사논문
Amino acid metabolism in cancer drug resistance
- Cells, 2022 Jan 2;11(1):140 | https://doi.org/10.3390/cells11010140
- 2022-01
- 의약학
- 상위피인용논문
Nutrient sensors and their crosstalk
- Exp. Mol. Med., 2023 Jun 1 | https://doi.org/10.1038/s12276-023-01006-z
- 2023-06
- 생명과학
- 한빛사논문
Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer
- Cancer Res., 2023 Mar 2;83(5):735-752 | https://doi.org/10.1158/0008-5472.CAN-22-2045
- 2023-03
- 생명과학
- 한빛사논문
O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
- Nat. Commun., Published 25 May 2022 | https://doi.org/10.1038/s41467-022-30696-8
- 2022-05
- 생명과학
- 한빛사논문
Glutamine reliance in cell metabolism
- Exp. Mol. Med., Published 17 September 2020 | https://doi.org/10.1038/s12276-020-00504-8
- 2020-09
- 생명과학
- 상위피인용논문
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
- Cell Metab., Available online 19 December 2019 | https://doi.org/10.1016/j.cmet.2019.11.020
- 2019-12
- 생명과학
- 한빛사논문, 상위피인용논문
Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway
- Proc. Natl. Acad. Sci. USA, Published ahead of print May 21, 2018 | https://doi.org/10.1073/pnas.1801287115
- 2018-05
- 생명과학
- 한빛사논문
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
- Nat. Commun., 8, Article number: 732 (2017) | doi:10.1038/s41467-017-00785-0
- 2017-09
- 생명과학
- 한빛사논문
Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
- Cell, Volume 149, Issue 2, 410-424, 15 March 2012 | DOI 10.1016/j.cell.2012.02.044
- 2012-03
- 생명과학
- 한빛사논문, 상위피인용논문

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